RNA Protein Homeostasis
Gene co-expression module in Lymphatic endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes: BAG1 (BAG cochaperone, proteasome-linked, anti-apoptotic), RAN (GTPase for nuclear transport), ILF2 (nuclear factor, RNA processing), ADRM1 (proteasome ubiquitin receptor, 26S proteasome lid), RBM8A (exon junction complex, RNA processing), SNRPB (spliceosome snRNP), SUB1 (transcriptional coactivator/RNA processing), COPRS (transcriptional repressor), SLC25A5 (mitochondrial ADP/ATP translocase), RAB32 (Rab GTPase, vesicle trafficking), UBE2B (E2 ubiquitin-conjugating enzyme). The module combines RNA processing (ILF2, RBM8A, SNRPB, SUB1), nuclear transport (RAN), ubiquitin-proteasome (ADRM1, UBE2B, BAG1), and vesicle/mitochondrial components. The delta_inflammation_CD is the highest positive in this batch (0.368), suggesting mild upregulation in inflammation. The mix of RNA processing and ubiquitin pathway genes with nuclear transport suggests a general RNA/protein homeostasis housekeeping program. Neighbor context: adjacent to proteasome modules (M55, M42) and translation (M26), consistent with proteostasis neighborhood.
Genes
ADRM1, BAG1, COPRS, ILF2, RAB32, RAN, RBM8A, SLC25A5, SNRPB, SUB1, UBE2B
Most correlated modules
- Oxidative Stress Response · correlation 0.92
- mRNA Translation Regulation · correlation 0.89
- Translation Elongation · correlation 0.84
- Integrated Stress Response · correlation 0.83
- NF-κB Autophagy Regulation · correlation 0.81
- DNA Damage Autophagy · correlation 0.79
- NF-κB Negative Feedback · correlation 0.78
- Proteasome Assembly · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.