NF-κB Negative Feedback
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes XBP1, NFKBIA, TNFAIP3, MAFF, NFIL3, and ICAM1 collectively define a NF-κB negative feedback and inflammatory resolution program. NFKBIA and TNFAIP3 (A20) are canonical NF-κB inhibitors induced by NF-κB activation itself. MAFF and NFIL3 are stress-responsive bZIP transcription factors. XBP1 links to ER stress/UPR. BMP2 and RHEB add morphogenic/mTOR context. The elevated delta_inflammation_CD (1.516) supports inflammatory context. As a neighbor to M65 (NF-κB activation), this module represents the counter-regulatory arm.
Genes
BMP2, C2CD4B, ICAM1, IRF8, KLF6, MAFF, NFIL3, NFKBIA, PRNP, PXDC1, RHEB, TNFAIP3, XBP1
Most correlated modules
- DNA Damage Autophagy · correlation 0.92
- NF-κB Inflammatory Activation · correlation 0.88
- Notch TGF-β Endothelial · correlation 0.86
- Integrated Stress Response · correlation 0.85
- Integrated Stress Response · correlation 0.84
- NF-κB Autophagy Regulation · correlation 0.83
- AhR mRNA Regulation · correlation 0.82
- Hypoxic Stress Response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.