DNA Damage Autophagy
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
GADD45A (DNA damage/stress sensor), MAP1LC3B (autophagosome marker, autophagy), ZC3H12A (MCPIP1, mRNA decay and inflammation resolution), PHLDA2 (stress/apoptosis), and TIFA (innate immune TRAF-interacting protein) converge on a DNA damage and autophagic stress response. CKS2 and HBP1 add cell cycle arrest context. NR1D1 links to circadian-metabolic regulation of stress. The module represents a cellular stress response integrating DNA damage sensing, autophagy induction, and mRNA decay.
Genes
CKS2, COQ10B, GADD45A, HBP1, MAP1LC3B, MSX1, NR1D1, PHLDA2, STX11, TIFA, ZC3H12A
Most correlated modules
- NF-κB Negative Feedback · correlation 0.92
- Integrated Stress Response · correlation 0.86
- NF-κB Autophagy Regulation · correlation 0.86
- NF-κB Inflammatory Activation · correlation 0.85
- Notch TGF-β Endothelial · correlation 0.84
- Hypoxic Stress Response · correlation 0.84
- Integrated Stress Response · correlation 0.82
- RNA Protein Homeostasis · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.