Hypoxic Stress Response
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
The top hub genes RRAD (p53/stress target), IER3 (immediate early stress response, NF-κB target), VEGFA (hypoxia-inducible angiogenic factor), IFRD1 (stress-responsive developmental regulator), and CCL2 (NF-κB/stress-induced chemokine) collectively define a hypoxic/cellular stress response program. ID2 and SOX4 are transcription factors active in vascular/lymphatic stress contexts. CHMP1B participates in endosomal stress pathways. The uniform expression across subsets and moderate detection rate are consistent with a broadly activated stress state in lymphatic endothelial cells rather than a subset-specific or contamination signal.
Genes
CCL2, CHMP1B, ID2, IER3, IFRD1, RRAD, SOX4, VEGFA
Most correlated modules
- Integrated Stress Response · correlation 0.88
- Notch TGF-β Endothelial · correlation 0.84
- DNA Damage Autophagy · correlation 0.84
- NF-κB Negative Feedback · correlation 0.81
- Lymphatic Valve Formation · correlation 0.80
- Heat Shock Chaperone · correlation 0.77
- NF-κB Inflammatory Activation · correlation 0.77
- Heat Shock Response · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.