Integrated Stress Response
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes PPP1R15A (GADD34, stress-induced phosphatase that dephosphorylates eIF2α), DDIT3 (CHOP, canonical ER/integrated stress response transcription factor), ATF3 (stress-responsive ATF/CREB family member), DNAJA1 and HSP90AB1 (chaperones upregulated under proteotoxic/ER stress) together define the integrated stress response (ISR) / unfolded protein response. CSRNP1 and SERTAD1 are stress-inducible genes; SRSF3 and EIF4A2 reflect translational reprogramming under stress. The module is tightly coherent (all core) and uniformly expressed. Neighbor M60 is a canonical heat-shock module, supporting a shared proteostasis/stress neighborhood. This module specifically captures the ISR arm (eIF2α phosphatase, CHOP, ATF3) rather than the HSP induction arm.
Genes
ATF3, CSRNP1, DDIT3, DNAJA1, EIF4A2, HSP90AB1, PPP1R15A, RSRC2, SERTAD1, SRSF3, TUBB4B
Most correlated modules
- Notch TGF-β Endothelial · correlation 0.88
- Hypoxic Stress Response · correlation 0.88
- DNA Damage Autophagy · correlation 0.86
- NF-κB Negative Feedback · correlation 0.85
- Heat Shock Chaperone · correlation 0.82
- Stress Granule Assembly · correlation 0.82
- Heat Shock Response · correlation 0.80
- NF-κB Inflammatory Activation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.