Heat Shock Response
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
The module is dominated by canonical cytoplasmic heat-shock proteins: HSPA6, HSPA1A, HSPA1B (Hsp70 family), DNAJB1, DNAJB4 (Hsp40 co-chaperones), HSP90AA1 (Hsp90α), HSPH1 (Hsp110), HSPB1 (Hsp27), BAG3 (Hsp70 co-chaperone), HSPE1 (Hsp10, mitochondrial chaperonin), ZFAND2A (AIRAP, proteasome activator under stress), and PDK4 (metabolic stress marker). All genes are core members. This is a textbook heat-shock / proteotoxic stress response module. Neighbor M47 captures the ISR arm of the same stress response, confirming the neighborhood represents coordinated proteostasis stress programs.
Genes
BAG3, DNAJB1, DNAJB4, HSP90AA1, HSPA1A, HSPA1B, HSPA6, HSPB1, HSPE1, HSPH1, PDK4, ZFAND2A
Most correlated modules
- Lymphatic Valve Formation · correlation 0.82
- Integrated Stress Response · correlation 0.80
- Heat Shock Chaperone · correlation 0.79
- Notch TGF-β Endothelial · correlation 0.77
- Hypoxic Stress Response · correlation 0.75
- AP-1 Immediate Early · correlation 0.69
- DNA Damage Response · correlation 0.64
- Stress Granule Assembly · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.