MPZL1 — Myelin protein zero like 1
MPZL1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MPZL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Proteolytic Fibroblast State ECM remodeling | ANXA2, CTSK, EMP3, LGALS3, PCOLCE, ROBO1, S100A10, S100A16 +3 more | View in SCUBA |
| Lymphatic endothelial | Apoptosis Immune Regulation Immune regulation | A4GALT, CFLAR, COX17, GRINA, NINJ1, OPTN, PAWR, RCN1 +2 more | View in SCUBA |
| Macrophages | Golgi-Endosome Trafficking Vesicular traficking | ACSL4, ADPGK, ARRDC3, ATXN7L3B, CLN8, DDB1, DNAJC2, ETS2 +26 more | View in SCUBA |
| Neutrophils | Immature Granulocyte Progenitor Developmental | ACSL4, AMPH, AVIL, CDC123, ENSG00000282804, HAL, HRH2, MAOA +3 more |
About the gene
| Synonyms | FLJ21047, PZR |
|---|---|
| Chromosome | 1: 167721192-167791919 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.