AhR mRNA Regulation
Gene co-expression module in Lymphatic endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
ZFP36L1 (TIS11B, AU-rich element mRNA decay), HNRNPDL and HNRNPH1 (hnRNP RNA-binding proteins) define a post-transcriptional mRNA regulation program. TIPARP (PARP7) and CYP1B1 are canonical AhR (aryl hydrocarbon receptor) target genes, suggesting AhR pathway activation. TRIM28 (KAP1) is a transcriptional co-repressor/chromatin regulator. ESAM is a lymphatic/endothelial junction molecule. SDC4 is a heparan sulfate proteoglycan involved in signaling. LIF is a cytokine. The module combines AhR-driven transcription with post-transcriptional mRNA decay regulation, possibly reflecting xenobiotic/AhR-mediated gene expression control in intestinal lymphatics.
Genes
CYP1B1, DHRS3, ESAM, HNRNPDL, HNRNPH1, LIF, SDC4, TIPARP, TPBG, TRIM28, TRIM8, ZFP36L1
Most correlated modules
- NF-κB Inflammatory Activation · correlation 0.86
- Integrated Stress Response · correlation 0.84
- Stress Kinase Signaling · correlation 0.82
- NF-κB Negative Feedback · correlation 0.82
- Apoptosis Immune Regulation · correlation 0.80
- NF-κB Autophagy Regulation · correlation 0.76
- NF-κB Inflammatory Activation · correlation 0.73
- Oxidative Stress Response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.