NF-κB Autophagy Regulation
Gene co-expression module in Lymphatic endothelial
| Category | Immune regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes RELB and NFKBIB are NF-κB family members/inhibitors; RNF114 is a ubiquitin E3 ligase that regulates NF-κB; SQSTM1 and GABARAPL1 are autophagy receptors/mediators; WTAP is the m6A methyltransferase adaptor. The module reflects NF-κB regulatory dampening coupled with selective autophagy, consistent with a negative feedback/resolution program. Neighbor M4 is a canonical NF-κB activation module, supporting this as the counter-regulatory arm.
Genes
CLIC2, GABARAPL1, LGMN, NFKBIB, OSER1, PRRG4, RELB, RNF114, SQSTM1, TMEM38B, WTAP, ZNF267
Most correlated modules
- DNA Damage Autophagy · correlation 0.86
- NF-κB Inflammatory Activation · correlation 0.85
- Integrated Stress Response · correlation 0.85
- NRF2 Oxidative Stress · correlation 0.84
- NF-κB Negative Feedback · correlation 0.83
- NRF2 Oxidative Stress · correlation 0.82
- RNA Protein Homeostasis · correlation 0.81
- Apoptosis Immune Regulation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.