LMAN1 — Lectin, mannose binding 1

LMAN1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LMAN1's module in each cell type

Cell type	Module	Shares the module with
Endothelial	Actin Cytoskeletal Remodeling Cytoskeletal	ACTB, ACTG1, ARF1, ARPC5L, CFL1, CYCS, DNAJB11, DNAJC1 +5 more	View in SCUBA
Fibroblasts	ER Protein Processing Vesicular traficking	ARPC2, ENO1, GTF3C6, KDELR2, OSTC, P4HB, PRDX4, PSMC4 +5 more	View in SCUBA
Goblet cells	ER Protein Translocation Protein processing & ER	DNAJC3, PDIA6, RPN2, SPCS2, SPCS3, SSR1, TMED10, TMED2	View in SCUBA
Innate lymphoid cells	ILC Transcription Factor Program Differentiation	APP, DCTN2, DEF6, GRAMD1A, GRHPR, HSD17B12, HSPB1, ILK +11 more	View in SCUBA
Lymphatic endothelial	Vascular Lumen Formation endothelial development	ANXA4, BLCAP, CD47, GINM1, MTDH, RASIP1, STAT1	View in SCUBA
Macrophages	ER-Lysosome Trafficking Vesicular traficking	BPNT2, CALU, CLPTM1L, CTSB, DHRS7, EMC10, GBA1, GNS +21 more	View in SCUBA

About the gene

Synonyms	ERGIC-53, ERGIC53, F5F8D, FMFD1, gp58, MCFD1, MR60
Chromosome	18: 59327823-59359265
Predicted location	Membrane
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Biological process	ER-Golgi transport, Protein transport, Transport

Function

Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.