SCUBA

IFRD1 — Interferon related developmental regulator 1

IFRD1 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IFRD1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsIntegrated Stress Response
Stress
AMD1, DDIT3, FAM133B, GOLGB1, MIDN, MKNK2, PHF1, PIM2 +4 moreView in SCUBA
CD4⁺ T cellsIntegrated Stress Response
Stress
CYCS, DDIT3, EIF1, EIF4A3, GTF2B, NASP, PTMA, TUBA1AView in SCUBA
FibroblastsCo-transcriptional RNA Processing
Housekeeping
FUS, INTS6, PCF11, PPP1R10, RSRP1, TSPYL2, YME1L1View in SCUBA
Gamma-delta T cellsTGF-beta Response
Immune regulation
ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A +15 more
Glial cellsHypoxia mTOR Stress
Stress
AMD1, CDKN2AIP, CITED2, DDIT4, HEXIM1, HSPA2, INTS6, NEU1 +3 moreView in SCUBA
Innate lymphoid cellsmTOR Stress Response
Stress
CEBPB, DDIT3, DDIT4, GLS, ID1, INTS6, JMJD6, KLF4 +9 moreView in SCUBA
Lymphatic endothelialHypoxic Stress Response
Stress
CCL2, CHMP1B, ID2, IER3, RRAD, SOX4, VEGFAView in SCUBA
MacrophagesSplicing Factor Regulation
Housekeeping
ARAP1, CCNL1, CELF1, CLK1, FAM53C, INPPL1, KIDINS220, MAN2C1 +12 moreView in SCUBA
Mucosal-associated invariant T cellIntegrated Stress Response
Stress
ATF4, EIF4A3, EIF5, FAM53C, MARCKSL1, MKNK2, ODC1, PLK2 +7 more
Natural Killer cellsTGF-β Antagonism
Immune regulation
IRS2, MOB3A, RBM39, SBDS, SMAD7, SRSF5, STK17B, ZBTB1 +1 moreView in SCUBA
NeutrophilsInflammasome IL-1 Response
Cytokine & chemokine secretion
CSRNP1, EGR3, G0S2, IER3, IL1B, IL1RN, IVNS1ABP, LPCAT1 +5 more
Smooth muscle cellsBAG3-HSPB8 proteostasis
Stress
BAG3, C6orf62, CREBRF, DNAJB4, EOGT, GOLGB1, HSPB8, PPP2R5E +5 moreView in SCUBA

About the gene

SynonymsPC4, TIS7
Chromosome7: 112422887-112481017
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classPredicted intracellular proteins, Predicted membrane proteins
Molecular functionDevelopmental protein
Biological processDifferentiation

Function

Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.