RRAD — RRAD, Ras related glycolysis inhibitor and calcium channel regulator
RRAD belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RRAD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ADRA2B, CD83, CHD4, CYB5D1, DUSP2, EGR2, EGR3, EGR4 +9 more | View in SCUBA |
| Innate lymphoid cells | ILC3 Transcriptional Identity Differentiation | ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1 +12 more | View in SCUBA |
| Lymphatic endothelial | Hypoxic Stress Response Stress | CCL2, CHMP1B, ID2, IER3, IFRD1, SOX4, VEGFA | View in SCUBA |
| Natural Killer cells | EGR2/3 NK Activation activation | AMD1, CHD4, CRTAM, CSF2, DNAJB9, EGR2, EGR3, GADD45A +4 more | View in SCUBA |
About the gene
| Synonyms | RAD, REM3 |
|---|---|
| Chromosome | 16: 66921679-66925536 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Calmodulin-binding |
Function
May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L- type Ca(2+) currents (By similarity). Regulates voltage-dependent L- type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin- dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.