TMEM120A — Transmembrane protein 120A
TMEM120A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM120A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | YAP Mechanotransduction migration & adhesion | COBLL1, CREB5, DEPP1, DST, FGL2, FLNC, FN1, GCNT2 +7 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | CASP8AP2, CNPPD1, CUL4A, CYBC1, EPRS1, FAM8A1, GTF2H3, IL17RA +15 more | |
| Lymphatic endothelial | Genotoxic Innate Inflammation Inflammation | CSF2, CSF3, E2F7, GBP2, NBN, PLA1A, RIPK2, SELENOM +1 more | View in SCUBA |
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more | View in SCUBA |
About the gene
| Synonyms | NET29, TACAN, TMPIT |
|---|---|
| Chromosome | 7: 75986831-75994656 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Immunity, Innate immunity |
Function
Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation. May function as a potential ion channel involved in sensing mechanical stimuli. Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction. TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (By similarity). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism. Additionnaly, implicated in innate immune response against Zika virus. Acts as a key activator of the antiviral signaling involving STING1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.