STAT3 Cytokine Signaling

Gene co-expression module in Mucosal-associated invariant T cell

Why this annotation

The top hub is STAT3 (strong membership), a pleiotropic transcription factor central to cytokine signaling (IL-6, IL-10, IL-21) and T cell function. WIPF1 is a WASp-interacting protein involved in actin polymerization and T cell activation. AKAP13 (BRX) is an A-kinase anchoring protein that also functions as a RhoA GEF. LCP1 (L-plastin) is an actin-bundling protein expressed in leukocytes and involved in T cell activation and migration. AKNA is a transcription factor regulating immune cell function. SF3B1 is a spliceosome component (RNA processing). GOLGB1 (giantin) is a Golgi structural protein. ARGLU1 is involved in RNA splicing and glucocorticoid signaling. SMG1 is a PI3K-like kinase involved in nonsense-mediated decay. AKIRIN2 links innate immune signaling to chromatin remodeling. H1-2 is a linker histone. BDP1 is part of the TFIIIB complex. The module is somewhat mixed but STAT3-centered cytokine signaling with actin/immune activation components is the clearest biological theme. The co-expression with M131 (STAT4) suggests a paired STAT signaling neighborhood representing MAIT cell homeostatic cytokine responsiveness.

Genes

AKAP13, AKIRIN2, AKNA, ARGLU1, BDP1, GOLGB1, H1-2, LCP1, PPP4R3B, SF3B1, SMG1, STAT3, WIPF1

Most correlated modules

• Chromatin & Splicing · correlation 0.84
• Lymphocyte Migration · correlation 0.83
• mRNA Processing Translation · correlation 0.77
• Rho GTPase Migration · correlation 0.75
• RUNX3 Tissue Identity · correlation 0.73
• Apoptosis Regulation · correlation 0.73
• NF-κB RNA Regulation · correlation 0.73
• Tissue Residency Regulation · correlation 0.73

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.