Apoptosis Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Immune regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include PCF11 (cleavage and polyadenylation factor, mRNA 3' processing), PPP1R10 (protein phosphatase 1 regulatory subunit, chromatin/nuclear functions), MAPRE2 (microtubule end-binding protein, cytoskeletal dynamics), and CFLAR (c-FLIP, key anti-apoptotic regulator of caspase-8/death receptor signaling). CARD8 (caspase recruitment domain, inflammasome/NF-kB), ARRDC3 (arrestin domain, receptor trafficking/ubiquitination), NABP1 (single-stranded DNA binding, DNA damage response), STK17A (DRAK2, pro-apoptotic serine/threonine kinase active in lymphocytes), CREBZF (CREB/ATF family transcription factor), and ARF4 (small GTPase, vesicle trafficking) round out the module. The dominant theme across hub and moderate-membership genes is regulation of cell survival vs. apoptosis: CFLAR inhibits death receptor apoptosis, CARD8 modulates inflammasome/caspase activity, STK17A promotes apoptosis, and NABP1 participates in DNA damage response. PCF11 and PPP1R10 add RNA processing and chromatin regulation. Together, the module reflects a cell survival/apoptosis regulatory program, consistent with MAIT cell persistence decisions in tissue contexts. Neighbor context with M84 (metabolic homeostasis) and M0 (tissue residency) supports a broadly homeostatic/survival program.
Genes
ARF4, ARRDC3, CARD8, CFLAR, CREBZF, MAPRE2, NABP1, PCF11, PPP1R10, STK17A
Most correlated modules
- Metabolic Homeostasis · correlation 0.82
- ER Stress Response · correlation 0.82
- TGF-β Immune Regulation · correlation 0.82
- RNA Splicing Processing · correlation 0.81
- Vesicle Membrane Trafficking · correlation 0.79
- Epigenetic Maintenance · correlation 0.78
- Chromatin Remodeling · correlation 0.76
- Chromatin & Splicing · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.