mRNA Processing Translation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes NONO (paraspeckle RNA binding protein), PRRC2A (RNA binding, mRNA stability), EIF4G1 (cap-dependent translation initiation scaffold), HNRNPU (mRNA export/processing), NCL (nucleolin, rRNA biogenesis), CSDE1 (RNA binding, IRES-mediated translation), DDX5 (RNA helicase, splicing/processing), ZFP36L1 (mRNA decay, AU-rich element binding) constitute a strong RNA processing and translation program. ACTN4 and MSN are cytoskeletal (actin cross-linker, ezrin-moesin), co-clustering possibly due to mRNA anchoring to cytoskeleton. GDI1 and CDC42SE1 link to Rho GTPase signaling. The dominant program is RNA metabolism/translation, and this module neighbors M18 (cytoskeletal) and M19 (chromatin/splicing), forming a broader housekeeping gene expression neighborhood.
Genes
ACTN4, CDC42SE1, CSDE1, DDX5, EIF4G1, GDI1, HNRNPU, MSN, NCL, NONO, NUCB1, PRRC2A, SMARCA5, TGOLN2, TM9SF2, ZFP36L1
Most correlated modules
- Chromatin Remodeling · correlation 0.81
- Chromatin & Splicing · correlation 0.80
- STAT3 Cytokine Signaling · correlation 0.77
- Nuclear-Cytoskeletal Organization · correlation 0.77
- Lymphocyte Migration · correlation 0.75
- NF-κB RNA Regulation · correlation 0.75
- Housekeeping Translation · correlation 0.72
- ER Protein Glycosylation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.