Lymphocyte Migration
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes STK10 (serine/threonine kinase 10, also called LOK, regulates lymphocyte migration via ezrin phosphorylation), MACF1 (microtubule-actin crosslinking factor, cytoskeletal organization), ROCK1 (Rho-associated kinase, actomyosin contractility and cell motility), IQGAP1 (cytoskeletal scaffold linking Rho GTPases to actin), and MPRIP (myosin phosphatase Rho-interacting protein, actomyosin) form a coherent cytoskeletal/migration program. RNF213 links to innate immune vascular biology. SP140 is an immune-specific nuclear body protein. OGA modulates cytoskeletal O-GlcNAcylation. Neighbors M92 and M95 share cytoskeletal elements (ACTN4, MSN), reinforcing a cytoskeletal neighborhood.
Genes
EFCAB14, IQGAP1, LNPEP, MACF1, MPRIP, OGA, PHF3, PTBP3, RNF213, ROCK1, SP140, STK10, UBR4
Most correlated modules
- Histone Modification · correlation 0.86
- STAT3 Cytokine Signaling · correlation 0.83
- Chromatin & Splicing · correlation 0.83
- Chromatin Remodeling · correlation 0.81
- RNA Splicing Processing · correlation 0.79
- TGF-β Immune Regulation · correlation 0.76
- Epigenetic Maintenance · correlation 0.75
- mRNA Processing Translation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.