Hypoxia-ER Stress
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
HIF1A is a central hub and master regulator of hypoxic/metabolic stress responses. EIF2AK3 (PERK) is a canonical ER stress and integrated stress response kinase. TP53BP2 links to p53-mediated stress signaling. ARID4B, ATXN7 (SAGA complex), ARID1A (SWI/SNF), and CTDP1 (RNA Pol II CTD phosphatase) reflect chromatin remodeling linked to stress-responsive transcription. ELF1 (ETS factor) and RNF19A (E3 ligase) may modulate this program. The co-occurrence of HIF1A and PERK suggests an integrated hypoxic/ER stress transcriptional response.
Genes
ANKHD1, ARID1A, ARID4B, ATXN7, CEMIP2, CPD, CTDP1, EIF2AK3, ELF1, HIF1A, RAB8B, RNF19A, TP53BP2, XPO6
Most correlated modules
- TCR Signal Attenuation · correlation 0.89
- T cell Quiescence · correlation 0.87
- Nuclear-Cytoplasmic Transport · correlation 0.87
- Post-translational Regulation · correlation 0.85
- Epigenetic Chromatin Regulation · correlation 0.81
- NF-κB Activation · correlation 0.79
- Transcriptional Co-regulation · correlation 0.74
- MAIT Cell Identity · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.