Post-translational Regulation

Gene co-expression module in Mucosal-associated invariant T cell

Why this annotation

This module is characterized by uniform, low-level expression across subsets with no clear dominant immune program. Hub genes include RELL1 (TNFR superfamily-related, apoptosis/death receptor signaling), MSL2 (E3 ubiquitin ligase, chromatin), PDZD8 (ER-mitochondria tethering), PDE4D (cAMP phosphodiesterase, immune signaling regulation), PRKX (cAMP-dependent kinase), RLF (zinc finger transcription factor), USP12 (deubiquitinase), PHF12 (chromatin/histone), POM121 (nuclear pore), GALC (lysosomal enzyme), MGAT4A (N-glycosylation), CCDC93 (retromer complex), CD55 (complement regulatory protein), KCTD20, KDM2B (histone demethylase), FBXO33, PSME4 (proteasome activator). The mixture of chromatin regulators, ubiquitin pathway, nuclear transport, glycosylation, and cAMP signaling suggests a general housekeeping/post-translational regulatory program. CD55 is notable as a complement inhibitor expressed on T cells. No tight single pathway emerges, pointing to a constitutive maintenance module.

Genes

CCDC93, CD55, FBXO33, GALC, KCTD20, KDM2B, MGAT4A, MSL2, PDE4D, PDZD8, PHF12, POM121, PRKX, PSME4, RELL1, RLF, USP12

Most correlated modules

• Autophagy & Trafficking · correlation 0.88
• Nuclear-Cytoplasmic Transport · correlation 0.87
• AP-1/MEF2 Activation · correlation 0.86
• Hypoxia-ER Stress · correlation 0.85
• Transcription Factor Activity · correlation 0.85
• Stress Granule Response · correlation 0.82
• T cell Quiescence · correlation 0.81
• RNA Processing Stress · correlation 0.77

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.