UBE2J1 — Ubiquitin conjugating enzyme E2 J1
UBE2J1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2J1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal Center Maturation B cell maturation | BCAS4, BCL7A, CCDC69, DCK, DTX1, ITGAE, LSM10, NEIL1 +5 more | View in SCUBA |
| Endothelial | Endothelial Membrane Transport Endothelial cell development | AQP1, CDH24, CEBPG, CLIC5, FAP, LSM6, OIT3, OSTF1 +9 more | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2 +15 more | |
| Macrophages | Antiviral ISG Response Antiviral | ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA 3' Processing RNA processing & translation | ATXN2L, CD6, DNM2, EIF4A2, HNRNPDL, MLLT6, NOP58, RBM15B +3 more | |
| Pericytes | RAS Cytoskeletal Signaling Cytoskeletal | ARPC5L, CNDP2, FAM177A1, KLF3, KRAS, LRRFIP1, PEA15, PTPN12 | View in SCUBA |
About the gene
| Synonyms | CGI-76, HSPC153, NCUBE1, UBC6 |
|---|---|
| Chromosome | 6: 89326625-89352722 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress. Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis. Also acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26. Plays a role in male fecundity through the interaction with the E3 ubiquitin-protein ligase RNF133. (Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'- linked ubiquitination on IRF3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.