ROCK1 — Rho associated coiled-coil containing protein kinase 1

ROCK1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ROCK1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Actomyosin signaling migration & adhesion	ACIN1, CYBC1, EIF4G3, GALNT1, HNRNPA3, NCKAP1L, PPP1R12A, PRKCH +8 more	View in SCUBA
Fibroblasts	Rho-ROCK Contractility Cytoskeletal	ANXA6, ATP2B4, CBX6, CSDE1, DYNLT3, GNG12, ITM2C, PPP1CB +1 more	View in SCUBA
Gamma-delta T cells	Rho GTPase Signaling Cytoskeletal	APOBR, ARHGEF3, ATP6V1H, BRCC3, CD46, CNDP2, CYB5R4, DCTN5 +14 more
Innate lymphoid cells	Golgi RNA Processing RNA processing & translation	ANKRD12, ATM, DDX17, GCC2, GOLGA4, LUC7L3, MIER1, MLEC +11 more	View in SCUBA
Lymphatic endothelial	Actomyosin Contractility Cytoskeletal	AFAP1L1, C1orf21, COBLL1, EEA1, GNB1, MAP4, OSBPL8, PPP1R12A +6 more	View in SCUBA
Macrophages	RNA Processing Housekeeping Housekeeping	BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 more	View in SCUBA
Mucosal-associated invariant T cell	Lymphocyte Migration migration & adhesion	EFCAB14, IQGAP1, LNPEP, MACF1, MPRIP, OGA, PHF3, PTBP3 +4 more
Smooth muscle cells	Vascular Tone Signaling Contractility	ADCY3, CPEB4, CYSTM1, DBI, EPAS1, EPS8, IER5L, NR2F2 +5 more	View in SCUBA

About the gene

Synonyms	p160ROCK
Chromosome	18: 20946906-21111813
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Apoptosis

Function

Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.