LNPEP — Leucyl and cystinyl aminopeptidase
LNPEP belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LNPEP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Actin Cytoskeletal Regulation Cytoskeletal | ACTR2, AP3B1, AP3M1, AZI2, CAPZA1, CEP250, CPSF3, DIDO1 +25 more | |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more | View in SCUBA |
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | EFCAB14, IQGAP1, MACF1, MPRIP, OGA, PHF3, PTBP3, RNF213 +4 more | |
| Natural Killer cells | NK Cell Activation activation | ACTG1, ACTR2, ACTR3, CD38, LCP1, MSN, TLN1, XPO1 | View in SCUBA |
| Neutrophils | S-G2-M Cell Cycle Cell cycle | ATAD2, CENPP, CNTRL, EZH2, MIS18BP1, RRM2, SMC4, TOPBP1 +1 more |
About the gene
| Synonyms | CAP, IRAP, P-LAP, PLAP |
|---|---|
| Chromosome | 5: 96935394-97037513 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins |
| Molecular function | Aminopeptidase, Hydrolase, Metalloprotease, Protease |
Function
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.