PSMD4 — Proteasome 26S subunit ubiquitin receptor, non-ATPase 4
PSMD4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMD4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | OxPhos & proteasome Mitochondrial & OxPhos | CCDC167, CLTA, COX17, COX5A, DBI, FKBP1A, FMNL1, GALM +10 more | View in SCUBA |
| CD8⁺ T cells | RNA Splicing Complex RNA processing & translation | ATP6V0B, ATP6V1F, EIF3I, MRPS6, NDUFS7, PARK7, PRDX6, SF3B5 +3 more | View in SCUBA |
| Endothelial | Rho-Actin Remodeling Cytoskeletal | ANAPC11, ARPC2, ARPC5, ATP6V0B, GNAI2, HNRNPH3, HRAS, KIF5B +9 more | View in SCUBA |
| Gamma-delta T cells | Glycolysis & Proteasome Housekeeping | ACAA2, ANAPC15, APEH, C1QBP, CCDC167, CHMP2A, CLNS1A, ENO1 +11 more | |
| Innate lymphoid cells | Proteasome & TCA Protein processing & ER | ACP1, ARPC5L, CAPZA1, CLTA, COPS9, HDAC1, MDH2, NDUFA1 +5 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Homeostasis Housekeeping | ATP5PB, COPZ1, FERMT3, GPS1, HMGN4, ICAM2, LAMTOR2, LCK +14 more |
About the gene
| Synonyms | AF, AF-1, Rpn10, S5A |
|---|---|
| Chromosome | 1: 151254709-151267479 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted intracellular proteins |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.