Integrin Actin Adhesion
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub TLN1 (talin-1) is a major integrin-actin linker essential for cell adhesion and migration. WASF2 (WAVE2) drives actin polymerization downstream of Rac1. ACTR2 (Arp2) is the actin-related protein 2 subunit of the Arp2/3 complex driving branched actin. SH3KBP1 (CIN85) is an adaptor involved in receptor endocytosis and cytoskeletal remodeling. PAK2 (p21-activated kinase 2) regulates actin dynamics. Together these define a cytoskeletal/adhesion program. Supporting genes: UGP2 (metabolic), TRIP11 (Golgi), JAK1 (cytokine signaling), PRKAA1 (AMPK), TAX1BP1 (NF-κB/autophagy), HP1BP3 (chromatin). The module is moderate coherence reflecting mixed programs, but the cytoskeletal/adhesion axis (TLN1, WASF2, ACTR2, PAK2, SH3KBP1) is the strongest identifiable theme.
Genes
ACTR2, ANKRD10, ATP2B1, DDX46, HP1BP3, HPS3, JAK1, LINS1, LRIF1, NCOR1, PAK2, PRKAA1, SH3KBP1, SP4, TAX1BP1, TLN1, TRIP11, UGP2, WASF2, ZBTB11
Most correlated modules
- Nuclear regulatory housekeeping · correlation 0.81
- Immune Synapse Signaling · correlation 0.79
- Endosomal Actin Organization · correlation 0.73
- Chemokine Receptor Migration · correlation 0.71
- T cell Homeostasis · correlation 0.69
- T cell Transcriptional Identity · correlation 0.68
- Chromatin Epigenetic Regulation · correlation 0.66
- TCR Activation Signaling · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.