Metabolic Homeostasis

Gene co-expression module in Mucosal-associated invariant T cell

Why this annotation

This module contains a diverse set of metabolic and regulatory genes with uniform expression across MAIT subsets. Hub genes include UAP1 (UDP-N-acetylglucosamine pyrophosphorylase, hexosamine biosynthesis), COQ10B (coenzyme Q binding, mitochondrial function), SLC3A2 (amino acid transporter, mTOR signaling), MPC2 (mitochondrial pyruvate carrier), ADIPOR1 (adiponectin receptor, fatty acid oxidation/AMPK), and KLF11 (metabolic transcription factor). Additional members like GNAI3 (G-protein signaling), BIRC3 (NF-kB/apoptosis inhibitor), LAG3 (immune checkpoint), and CREBRF (CREB regulatory factor stress response) add signaling/regulatory diversity. The module does not cluster cleanly into a single tight pathway but broadly reflects cellular metabolic homeostasis — nutrient sensing, amino acid and lipid metabolism, mitochondrial substrate handling. LAG3 is notable as an exhaustion/immune checkpoint marker but is a moderate/weak peripheral member. The dominant theme across the high-PageRank hub genes is metabolic regulation and nutrient sensing rather than immune effector function. Neighbor context with M0 and M132 (both containing anti-apoptotic, regulatory, and transcription factor genes) supports a broadly homeostatic/regulatory program.

Genes

ADIPOR1, BIRC3, COQ10B, CREBRF, EIF1AX, GNAI3, H2AC20, KLF11, KLHL18, KRR1, LAG3, LAP3, MPC2, PTMS, SLC3A2, TSPOAP1, TYMP, UAP1, ZNF10

Most correlated modules

• Tissue Residency · correlation 0.93
• NF-κB Survival Signaling · correlation 0.88
• NF-κB Activation · correlation 0.82
• Apoptosis Regulation · correlation 0.82
• Rho GTPase Migration · correlation 0.81
• Vesicle Membrane Trafficking · correlation 0.81
• Epigenetic Maintenance · correlation 0.81
• Oxidative Stress Response · correlation 0.81

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.