PTPN1 — Protein tyrosine phosphatase non-receptor type 1
PTPN1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activated B cell B cell maturation | ARHGAP25, ARID3A, CFLAR, DUSP4, ENTPD1, MYO1F, PIK3R5, PLXNC1 +6 more | View in SCUBA |
| CD4⁺ T cells | Th1 IL12 response Immune regulation | ADCY3, AKIRIN2, CTNNA1, ETV7, HIVEP3, IL12RB2, JAKMIP1, RFTN1 +2 more | View in SCUBA |
| Gamma-delta T cells | ER Stress Response Stress | ATP1B3, ATP2A2, BACH1, CPD, EIF2AK3, FAM118A, G3BP2, GRK5 +13 more | |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | Rho GTPase Migration migration & adhesion | GNA13, HAPSTR1, HIPK1, LEMD3, LUZP1, MYO9B, PPP1CB, PPP1R16B +4 more |
About the gene
| Synonyms | PTP1B |
|---|---|
| Chromosome | 20: 50510321-50585241 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.