SPTAN1 — Spectrin alpha, non-erythrocytic 1
SPTAN1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPTAN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin regulation DNA/chromatin regulation | ANKRD11, BIRC6, CNTRL, EP300, FAM118A, GOLGA4, IRF2, KAT6A +12 more | View in SCUBA |
| Endothelial | Cytoskeletal Scaffolding Cytoskeletal | ADD1, AGPAT1, ANO6, ARL6IP5, CDC42BPA, CHURC1, DOCK1, ERC1 +6 more | View in SCUBA |
| Gamma-delta T cells | ER Antigen Processing Protein processing & ER | ACLY, ATL3, ATR, CANX, DCTN1, DDB1, ERAP1, FOXJ3 +9 more | |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear-Cytoskeletal Organization Housekeeping | DDB1, GANAB, HYOU1, IPO7, MYH9, NOLC1, NUMA1, PRPF8 +4 more |
About the gene
| Chromosome | 9: 128552558-128633662 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Actin capping, Actin-binding, Calmodulin-binding |
Function
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.