PRKX — Protein kinase cAMP-dependent X-linked catalytic subunit
PRKX belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRKX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Atypical memory B cell B cell maturation | FCRL5, FGR, HCK, HEXA, HMOX1, ITGAX, LRRK2, MED13L +5 more | View in SCUBA |
| Gamma-delta T cells | Circadian Clock DNA/chromatin regulation | BHLHE40, CDK17, CPEB2, CRY1, IRF1, ITPRIP, MEF2D, NR1D2 +5 more | |
| Innate lymphoid cells | Lymphocyte Apoptosis Regulation Immune regulation | ANP32B, ARMCX3, CCDC69, CHD2, DHRS7, ELF1, FXYD5, GLIPR1 +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Post-translational Regulation Housekeeping | CCDC93, CD55, FBXO33, GALC, KCTD20, KDM2B, MGAT4A, MSL2 +8 more | |
| Natural Killer cells | NF-κB Activation Inflammation | ADGRE5, BCL3, BHLHE40, CSRNP1, DUSP10, NFKB1, NFKB2, NINJ1 +3 more | View in SCUBA |
About the gene
| Synonyms | PKX1 |
|---|---|
| Chromosome | X: 3604340-3713649 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Angiogenesis, Differentiation |
Function
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular- like structure formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.