PCBP1 — Poly(rC) binding protein 1
PCBP1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCBP1's module in each cell type
About the gene
| Synonyms | hnRNP-E1, hnRNP-X, HNRPE1, HNRPX |
|---|---|
| Chromosome | 2: 70087477-70089203 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Ribonucleoprotein, RNA-binding |
| Biological process | Viral RNA replication |
Function
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.