Chromatin Complex Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
Top hub genes RBBP4 (histone chaperone in NuRD/CAF-1 complexes), TADA3 (SAGA complex acetyltransferase module), RUVBL1 (AAA-ATPase in chromatin remodeling complexes including INO80/TIP60), HDAC7 (class II histone deacetylase), and CHTF8 (chromatid cohesion factor) collectively define a chromatin regulatory complex program. CCND2 (cyclin D2) connects to cell cycle entry. UBLCP1 (ubiquitin-like modifier protease) participates in proteasome regulation. GDI2 and HCLS1 are lymphocyte-specific housekeeping factors. Neighbor M38 also features chromatin regulators (RBL2, ATRX), reinforcing the chromatin regulatory neighborhood.
Genes
APEH, CAPZB, CCND2, CFH, CHTF8, ESYT1, GDI2, HACD4, HCLS1, HDAC7, IL16, KRI1, MRFAP1L1, NCKAP1L, RBBP4, RUVBL1, TADA3, UBLCP1
Most correlated modules
- Chromatin Maintenance State · correlation 0.83
- Endosomal Actin Organization · correlation 0.83
- T cell Activation Signaling · correlation 0.82
- Cytoskeletal Remodeling Migration · correlation 0.80
- Mature Effector MAIT · correlation 0.79
- MAIT Effector Maturation · correlation 0.78
- IL-12 Cytotoxic Effector · correlation 0.76
- TCR Signaling Identity · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.