Cytoskeletal Migration
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Top hub SSH2 is a slingshot phosphatase that activates cofilin to drive actin depolymerization and cell motility. NCAM1 (CD56) is an adhesion molecule expressed on effector MAIT and NK cells mediating cell-cell contact. RASA2 is a RAS GTPase-activating protein regulating migration signals. HDAC9 is a class IIa HDAC with roles in T cell regulation and migration. MGAT5 modifies N-glycans on surface receptors affecting adhesion and signaling. PITPNC1 regulates phosphoinositide lipids involved in actin and migration. CHST11 modifies proteoglycans relevant to ECM interactions. NCOA2 is a nuclear receptor coactivator. Together SSH2+NCAM1+RASA2+PITPNC1 form a coherent actin/cytoskeletal and adhesion program in MAIT effector cells. As a neighbor of M78, both modules likely represent programs active in mature/effector MAIT cells with large regulatory gene bodies.
Genes
CHST11, HDAC9, MGAT5, NCAM1, NCOA2, PITPNC1, RASA2, SSH2
Most correlated modules
- SWI/SNF Chromatin Remodeling · correlation 0.90
- Calcineurin-NFAT Signaling · correlation 0.82
- RAS-GEF Signaling · correlation 0.80
- Lymphocyte Migration · correlation 0.79
- Chromatin Remodeling · correlation 0.78
- STAT4 T cell Identity · correlation 0.75
- TCR Activation Signaling · correlation 0.73
- IL-18 Innate Activation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.