SWI/SNF Chromatin Remodeling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 22 genes have a known function matching the annotation |
Why this annotation
ARID1B and ARID2 are subunits of the SWI/SNF chromatin remodeling complex (BAF/PBAF), which is critical for T cell differentiation and gene regulation. BRAF and MAPK8 (JNK1) are MAPK pathway kinases. VAV3 is a Rho-family GEF downstream of TCR/BCR. PRKCH (PKC-eta) is a PKC isoform involved in T cell signaling. DYRK1A phosphorylates NFAT to promote nuclear export. NUP153 is a nuclear pore component regulating gene expression. CNOT6L is part of CCR4-NOT mRNA deadenylation complex. PTPRJ (CD148) is a receptor-type phosphatase regulating T cell activation. HIVEP2 is a NF-κB-related transcription factor. UBR5 and RNF38 are E3 ubiquitin ligases. The module integrates chromatin remodeling with MAPK signaling, consistent with gene regulatory responses during T cell activation.
Genes
ABTB3, AOAH, ARID1B, ARID2, ATP8A1, ATXN1, BRAF, CCSER2, CDC42SE2, CNOT6L, DYRK1A, HIVEP2, MAPK8, NUP153, PDGFD, PRKCH, PTPRJ, RNF38, SIPA1L1, SUPT3H, UBR5, VAV3
Most correlated modules
- Cytoskeletal Migration · correlation 0.90
- RAS-GEF Signaling · correlation 0.89
- Lymphocyte Migration · correlation 0.86
- Calcineurin-NFAT Signaling · correlation 0.82
- TCR Activation Signaling · correlation 0.79
- Chromatin Remodeling · correlation 0.76
- IL-18 Innate Activation · correlation 0.74
- Cellular Maintenance · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.