Calcineurin-NFAT Signaling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
PPP3CA (calcineurin A, CnA) is the catalytic subunit of calcineurin, the Ca2+/calmodulin-dependent phosphatase that dephosphorylates NFAT and drives T cell gene expression. PLCB1 generates IP3 and DAG downstream of GPCRs, raising intracellular Ca2+. PLCL2 is a PLC-like protein regulating ITAM signaling. NCALD is a Ca2+ sensor protein. AKT3 is the PI3K/Akt pathway effector. PPP2R2B is a PP2A regulatory subunit (B55β) that counters Akt signaling. NEK7 is a kinase involved in NLRP3 inflammasome and cell cycle. CDC14A is a phosphatase regulating cell cycle exit. TBC1D22A is a Rab GAP. IQGAP2 scaffolds Ca2+/calmodulin signaling. SPIDR is involved in DNA repair. The calcineurin-NFAT axis (PPP3CA, PLCB1, NCALD, AKT3, IQGAP2) is the dominant biological theme, consistent with Ca2+-dependent T cell activation.
Genes
AKT3, CDC14A, IQGAP2, NCALD, NEK7, PLCB1, PLCL2, PPP2R2B, PPP3CA, SPIDR, TBC1D22A, VWA8
Most correlated modules
- Chromatin Remodeling · correlation 0.91
- Lymphocyte Migration · correlation 0.90
- Cytoskeletal Migration · correlation 0.83
- Cytoskeletal Migration · correlation 0.82
- SWI/SNF Chromatin Remodeling · correlation 0.82
- Immune Synapse Signaling · correlation 0.81
- RAS-GEF Signaling · correlation 0.77
- TCR Activation Signaling · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.