STAT4 T cell Identity
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
The top hub gene is STAT4 (core membership), a transcription factor critical for IL-12 signaling and Th1/Tc1 differentiation, highly relevant to MAIT cell effector programming. IKZF1 (Ikaros) is a master lymphoid transcription factor. CD96 is an NK/T cell receptor (TIGIT family) involved in immune regulation and cytotoxicity. CELF2 regulates mRNA stability and is important in T cell activation. CBLB is an E3 ubiquitin ligase that attenuates TCR signaling (immune tolerance). JMJD1C is a histone demethylase linked to T cell function. SMARCA2 and SMCHD1 are chromatin remodelers. CAMK4 mediates calcium-dependent signaling in T cells. SIK3 is a salt-inducible kinase involved in immune regulation. This module reflects a MAIT cell maturation/identity program centered on STAT4-driven transcriptional programming, T cell regulatory signaling (CBLB, CAMK4), and chromatin accessibility (SMARCA2), consistent with a mature effector MAIT phenotype. Neighbor context (M26 migration, M123 STAT3) supports a homeostatic mature T cell regulatory network.
Genes
ATF7IP, CAMK4, CBLB, CD96, CELF2, DENND4A, IKZF1, JMJD1C, PIP4K2A, SIK3, SLK, SMARCA2, SMCHD1, STAT4, TTC39C, USP15
Most correlated modules
- Calcium Signal Integration · correlation 0.80
- TGF-β Immune Regulation · correlation 0.79
- Chromatin Epigenetic Regulation · correlation 0.78
- Cytoskeletal Migration · correlation 0.75
- RUNX3 Tissue Identity · correlation 0.73
- Histone Modification · correlation 0.71
- SWI/SNF Chromatin Remodeling · correlation 0.70
- STAT3 Cytokine Signaling · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.