PHF19 — PHD finger protein 19
PHF19 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHF19's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle Proliferation Cell cycle | ALYREF, ANP32E, BCL2L12, BIRC5, BUB3, CENPW, CEP55, CKS1B +4 more | View in SCUBA |
| Endothelial | Mitotic Spindle Cell cycle | ASPM, CCNB1, CDK1, CENPE, CENPF, CKAP2, KIF20B, KNSTRN +14 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN +13 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
| Natural Killer cells | G2/M Transition Cell cycle | ANP32B, CARHSP1, NSD2, SMC2, STMN1, TMPO, TUBA1B, TUBB | View in SCUBA |
About the gene
| Synonyms | DKFZP727G051, MTF2L1, PCL3, TDRD19B |
|---|---|
| Chromosome | 9: 120855651-120894896 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self- renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.