PTPN18 — Protein tyrosine phosphatase non-receptor type 18
PTPN18 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPN18's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Actin cytoskeleton remodeling Cytoskeletal | ACTR2, BASP1, CAPZA1, CDV3, EIF3A, FAM107B, GRB2, HCLS1 +9 more | View in SCUBA |
| CD4⁺ T cells | Th17 effector Th17 fate | CD6, CLSTN3, CTDSP1, IL17A, ITPRIPL2, MAP3K4, MPRIP, NFIL3 +6 more | View in SCUBA |
| Innate lymphoid cells | Actin Cytoskeletal Regulation Cytoskeleton & motility | AQP3, CCDC57, CLPTM1, COTL1, DCAF11, GSN, GYG1, MZT2B +7 more | View in SCUBA |
| Macrophages | Endosomal Membrane Trafficking Vesicular traficking | A2M, AP1B1, ARHGAP4, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | PI3K-Calcineurin Signaling TCR Signaling | ACLY, BCL9L, CABIN1, CDK11A, LATS2, NBPF19, NUP210, PIK3CD +2 more | |
| Natural Killer cells | Actin Cytoskeleton Remodeling Cytoskeleton & motility | ANXA6, ARPC1B, ARPC4, BAX, CAPNS1, CAPZB, GNAI2, IL2RG +7 more | View in SCUBA |
About the gene
| Synonyms | BDP1 |
|---|---|
| Chromosome | 2: 130356045-130375405 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.