EGR2/3 NK Activation
Gene co-expression module in Natural Killer cells
| Category | activation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
EGR2 and EGR3 are the defining transcription factors of NK cell maturation, licensing, and exhaustion — their co-expression is a hallmark of NK activation/exhaustion programs. RRAD (Ras-related, stress-responsive), GADD45A (DNA damage/stress response), AMD1 (polyamine biosynthesis, linked to activation), RGS16 (negative regulator of GPCR/chemokine signaling), CRTAM (cytotoxic NK/T activation marker expressed upon activation), CSF2 (GM-CSF, effector cytokine), MIDN (midnolin, stress-related), DNAJB9 (ER chaperone/stress). The module is strongly upregulated in CD inflammation and suppressed in remission. EGR2/EGR3-driven program consistent with NK activation and potential exhaustion entry.
Genes
AMD1, CHD4, CRTAM, CSF2, DNAJB9, EGR2, EGR3, GADD45A, MAP2K3, MIDN, RGS16, RNF19A, RRAD
Most correlated modules
- NF-κB Activation · correlation 0.92
- TGF-beta Repression · correlation 0.90
- NRF2 Stress Response · correlation 0.84
- Transcription Elongation Control · correlation 0.84
- NK Activation Response · correlation 0.83
- ER Stress Response · correlation 0.82
- Cytokine Feedback Response · correlation 0.81
- Metabolic Activation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.