Integrated Stress Response
Gene co-expression module in Natural Killer cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
PPP1R15A (GADD34) and PPP1R15B (CReP) are both regulatory subunits of PP1 that dephosphorylate eIF2α — the core effectors of the integrated stress response (ISR). PMAIP1 (NOXA) is a pro-apoptotic BH3-only protein induced by stress and NF-κB. NFKBIA and NFKBIZ are IκB family negative regulators providing NF-κB feedback. IER2 and IER5 are immediate early response genes. ZBTB10 is a transcriptional repressor. MARCKSL1 is an actin-binding protein. The module is upregulated in CD inflammation and reduced with CD treatment, consistent with a stress/NF-κB feedback response. PPP1R15A/B co-expression defines the ISR recovery arm.
Genes
FAM43A, IER2, IER5, MARCKSL1, NFKBIA, NFKBIZ, PMAIP1, PPP1R15A, PPP1R15B, ZBTB10
Most correlated modules
- AP-1 Immediate Early · correlation 0.86
- Autophagy-Inflammation Stress · correlation 0.85
- NF-κB Activation · correlation 0.84
- TGF-beta Repression · correlation 0.81
- Transcription Elongation Control · correlation 0.80
- ER Stress Response · correlation 0.79
- EGR2/3 NK Activation · correlation 0.78
- NK Activation Response · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.