RNF166 — Ring finger protein 166
RNF166 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNF166's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon response Anti-viral | ACBD5, AQP3, BTN2A1, BTN3A2, BTN3A3, CISH, EIF2AK2, ERAP2 +23 more | View in SCUBA |
| Gamma-delta T cells | Innate Stress Signaling Inflammation | AKT3, B4GALT4, BCR, BLOC1S4, COL6A2, CREBRF, DGKQ, ELF2 +23 more | |
| Mucosal-associated invariant T cell | TGF-beta Response Immune regulation | ABCA1, ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1 +21 more | |
| Natural Killer cells | Lymphocyte Trafficking Homing & TEM | BCL6, CTSD, LAPTM5, LITAF, ORAI1, P2RY8, PTPRJ, S1PR1 +3 more | View in SCUBA |
About the gene
| Synonyms | MGC14381, MGC2647 |
|---|---|
| Chromosome | 16: 88696499-88706408 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Autophagy, Immunity, Innate immunity, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Also plays a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.