NASP — Nuclear autoantigenic sperm protein

NASP belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NASP's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	mRNA splicing factors RNA processing	CALM1, CALM2, CKS2, CYCS, EIF4A3, HNRNPA0, HNRNPA2B1, HNRNPAB +12 more	View in SCUBA
CD4⁺ T cells	Integrated Stress Response Stress	CYCS, DDIT3, EIF1, EIF4A3, GTF2B, IFRD1, PTMA, TUBA1A	View in SCUBA
CD8⁺ T cells	Epigenetic Chromatin Maintenance DNA/chromatin regulation	BAZ1B, DDX46, DNMT1, HNRNPAB, NOP56, SET, SMC1A, SMC3 +2 more	View in SCUBA
Gamma-delta T cells	G1/S Entry Cell cycle	CDKN2A, CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2 +15 more
Goblet cells	MCM Replication Licensing Cell cycle	CDT1, DNMT1, DUT, FAM111B, GINS2, HELLS, MCM3, MCM4 +4 more	View in SCUBA
Innate lymphoid cells	Transcriptional Activation DNA regulation & transcription	AKIRIN1, CHORDC1, FAM133B, FAM53C, GOLGB1, GTF2B, IDI1, MORF4L2 +9 more	View in SCUBA
Macrophages	Centrosome & DNA Repair Cell cycle	ANKRD13A, BRCA2, CASP2, CBX5, CCDC14, CEP152, CEP78, CKAP5 +34 more	View in SCUBA
Mucosal-associated invariant T cell	Anti-inflammatory Homing Tissue residence	ANXA1, GPR183, PNP, TAGLN2, TUBA1C, UBE2A, VIM, YWHAQ
Natural Killer cells	S/G2M Cell Cycle Cell cycle	CALM2, CDK2AP2, CKS2, JPT1, KPNA2, NAP1L1, PRDX1, TUBA1C	View in SCUBA

About the gene

Synonyms	DKFZp547F162, FLB7527, FLJ31599, FLJ35510, MGC19722, MGC20372, MGC2297, PRO1999
Chromosome	1: 45583846-45618904
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Biological process	Cell cycle, DNA replication, Protein transport, Transport

Function

Component of the histone chaperone network. Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy. Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. Stabilizes soluble histone H3-H4. Stabilizes soluble histone H3-H4

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.