TRAT1 — T cell receptor associated transmembrane adaptor 1
TRAT1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRAT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | ACVR1C, ADA2, ANK3, CAMK4, CHD7, GCLM, GNAO1, MPP7 +15 more | View in SCUBA |
| CD8⁺ T cells | Effector-Memory CD8 T cell maturation | CD27, CD44, CMC1, CST7, CXCR3, DUSP2, EOMES, F2R +8 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more | |
| Mucosal-associated invariant T cell | T cell Homeostasis T cell maturation | APOL6, CD40LG, CNDP2, FAM118A, FCMR, GPR171, IFIH1, IL7R +19 more | |
| Natural Killer cells | Gut-Homing NK Gut residency | CCR9, FAM3C, GRAMD2B, OXNAD1, PLPP1, PRKAR2B, SMIM3, SNX9 | View in SCUBA |
About the gene
| Synonyms | HSPC062, TCRIM, TRIM |
|---|---|
| Chromosome | 3: 108822770-108855005 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.