MAPK/AP-1 Signaling
Gene co-expression module in Natural Killer cells
| Category | Inflammation |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include RALGAPA1 (RAL GTPase activating protein, regulates vesicle trafficking and Ras signaling), VPS37B (ESCRT-I complex, endosomal sorting), FAM177A1 (poorly characterized), B3GNT7 (glycosyltransferase), SYAP1 (synapse-associated protein), FOSL2 (AP-1 transcription factor, inflammatory gene regulation), TIPARP (PARP7, ADP-ribosyltransferase, regulates AhR and inflammatory signaling), PDE4B (phosphodiesterase 4B, cAMP degradation, key regulator of NK/immune cell activation), BRAF (MAP kinase pathway), PIK3R1 (PI3K regulatory subunit), and SDCBP (syndecan binding protein/syntenin, involved in exosome biogenesis and signaling). The module is significantly upregulated in CD inflammation. FOSL2, TIPARP, PDE4B, BRAF, and PIK3R1 collectively point to MAPK/AP-1 and PI3K signaling activation. RALGAPA1 and VPS37B suggest vesicle/endosomal trafficking. This module likely represents inflammatory signal transduction through MAPK/AP-1 pathways in NK cells during CD.
Genes
B3GNT7, BRAF, FAM177A1, FOSL2, GPBP1, PDE4B, PIK3R1, RALGAPA1, SDCBP, SYAP1, TENT5C, TIPARP, VPS37B
Most correlated modules
- NK Activation Response · correlation 0.91
- NRF2 Stress Response · correlation 0.85
- NK Cell Activation · correlation 0.85
- TGF-beta Repression · correlation 0.84
- NK Immune Checkpoint · correlation 0.82
- NF-κB Activation · correlation 0.81
- TGF-β Antagonism · correlation 0.81
- Cytokine Feedback Response · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.