MAFF — MAF bZIP transcription factor F

MAFF belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MAFF's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Immediate Early AP-1 TCR/AP1/NFKb pathway	BTG2, CD69, CDKN1A, DUSP1, EGR1, FOS, FOSB, IER2 +6 more	View in SCUBA
Endothelial	Integrated Stress Response Stress	ARL5B, ATF3, CCNL1, CD83, CDKN1A, DDIT3, ICAM4, IRF1 +3 more	View in SCUBA
Fibroblasts	NF-κB Immediate Early Inflammatory	ATF3, DNAJA1, DUSP1, HLA-E, HSPA8, IRF1, NFKBIA, NFKBIZ +4 more	View in SCUBA
Gamma-delta T cells	NF-κB Activation Inflammation	DUSP5, GADD45A, HERPUD1, IL21R, KDM6B, NAMPT, NFKB1, NFKB2 +13 more
Glial cells	Integrated Stress Response Stress	ATF3, CCNL1, DNAJA1, DUSP1, HSPA8, HSPH1, KLF4, NR4A1 +2 more	View in SCUBA
Goblet cells	NF-κB Stress Response Stress	ATF3, CCNL1, EGR3, IER3, MYADM, NFKBIA, NR4A1, RHOB +1 more	View in SCUBA
Innate lymphoid cells	NR4A Activation Response activation	ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1 +16 more	View in SCUBA
Lymphatic endothelial	NF-κB Negative Feedback Inflammation	BMP2, C2CD4B, ICAM1, IRF8, KLF6, NFIL3, NFKBIA, PRNP +4 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Monocytes	Integrated Stress Response Stress	CDKN1A, CSRNP1, EIF2AK3, HBEGF, KLF10, PIM3, TIPARP	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Activation Inflammation	DUSP5, DUSP8, ELL2, GABARAPL1, IRF2BP2, NAMPT, NFKB1, PER1 +8 more
Natural Killer cells	NK Activation Response activation	CREM, EIF1, FTH1, NR4A2, SELENOK, SRGN, ZNF331	View in SCUBA
Neutrophils	Chemokine Secretion Cytokine & chemokine secretion	CXCL1, CXCL2, CXCL8, DDIT3, GADD45B, GLUL, HCAR2, IER5 +3 more
Smooth muscle cells	Immediate Early Response Stress	ABHD5, ARC, ARL5B, BRD2, DDIT3, EGR3, GDF11, HEXIM1 +4 more	View in SCUBA

About the gene

Synonyms	hMafF
Chromosome	22: 38200767-38216507
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, Repressor
Biological process	Stress response, Transcription, Transcription regulation

Function

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.