Chaperonin heat-shock
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Dominated by the mitochondrial chaperonin pair HSPD1/HSPE1 together with DUSP1 (immediate-early stress phosphatase), ODC1 and SLC25A25 (stress/energy-responsive mitochondrial carrier), UBE2D3 (ubiquitin conjugation) and the housekeeping translation factors SRSF3/PABPC1. This mixes a heat-shock/proteotoxic stress core with abundant translation machinery, matching its neighbor M89 (BAG3/HSPB8/DNAJB4 chaperones) — the shared driver is a proteostatic/heat-shock response rather than a discrete lineage program.
Genes
CYCS, DUSP1, HSPD1, HSPE1, ODC1, PABPC1, SLC25A25, SRSF3, UBE2D3
Most correlated modules
- Secondary Response Genes · correlation 0.75
- hnRNP & Proteasome · correlation 0.74
- KLF6/ZNF24 regulators · correlation 0.69
- Immediate Early Response · correlation 0.68
- Translation initiation/RNA-binding · correlation 0.67
- STAT3 transcriptional program · correlation 0.67
- NR4A-ADAMTS Activation · correlation 0.67
- Cytoskeletal trafficking kinases · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.