Translation initiation/RNA-binding
Gene co-expression module in Smooth muscle cells
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Core members are translation and RNA-binding/processing machinery: EIF5 (initiation factor), FUS (RNA-binding), CDV3 (translation-associated), TCP1 (CCT chaperonin folding nascent chains), PPP1R10/PNUTS (nuclear PP1 in RNA processing), plus chromatin/TF genes (EPC1, ZEB1, MAFB) as peripheral members. Coherence is moderate, consistent with a translation/RNA-processing backbone with some regulatory hitchhikers; it neighbors M124 (SRSF3/PABPC1) supporting a shared biosynthetic axis.
Genes
BRI3, CDV3, EIF5, EPC1, FAM133B, FAM53C, FUS, MAFB, PPP1R10, TCP1, ZEB1
Most correlated modules
- STAT3 transcriptional program · correlation 0.74
- BAG3-HSPB8 proteostasis · correlation 0.71
- BMP/TGF-beta response · correlation 0.68
- Chaperonin heat-shock · correlation 0.67
- Immediate Early Response · correlation 0.64
- KLF6/ZNF24 regulators · correlation 0.61
- NF-kB Stress Response · correlation 0.60
- NR4A-ADAMTS Activation · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.