NR4A-ADAMTS Activation
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 14 genes have a known function matching the annotation |
Why this annotation
Driven by the NR4A orphan nuclear receptor family (NR4A1/2/3) together with MYC, ZNF331, KLF9, RASD1, DUSP8, HIPK2 and PHLDA1 — a coherent secondary immediate-early/serum-response transcription program. Coupled to it are the stress/activation-inducible secreted metalloproteases ADAMTS1, ADAMTS4 and ADAMTS9 (top hub), which are direct NR4A/AP-1 target genes in smooth muscle and fibroblasts and mediate proteoglycan (versican) turnover. AVPR1A reflects the visceral SMC GPCR context. Uniform expression with no foreign-lineage enrichment; its neighbors M79/M91 confirm this is the NR4A-driven arm of the same acute activation cascade, here with an ECM-proteolysis output.
Genes
ADAMTS1, ADAMTS4, ADAMTS9, AVPR1A, DUSP8, HIPK2, KLF9, MYC, NR4A1, NR4A2, NR4A3, PHLDA1, RASD1, ZNF331
Most correlated modules
- NF-kB Stress Response · correlation 0.77
- Secondary Response Genes · correlation 0.74
- Immediate Early Response · correlation 0.70
- Chaperonin heat-shock · correlation 0.67
- STAT3 transcriptional program · correlation 0.61
- XBP1 UPR Response · correlation 0.58
- Translation initiation/RNA-binding · correlation 0.57
- Capillary Pericyte · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.