SCUBA

SRSF3 — Serine and arginine rich splicing factor 3

SRSF3 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SRSF3's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsmRNA splicing factors
RNA processing		CALM1, CALM2, CKS2, CYCS, EIF4A3, HNRNPA0, HNRNPA2B1, HNRNPAB +12 moreView in SCUBA
CD4⁺ T cellsUnfolded Protein Response
Protein processing & ER		ARF4, ATF4, DUSP8, HSPA5, IL23A, NLRP3, NOP56, NRIP3 +7 moreView in SCUBA
FibroblastsHeat Shock Response
Stress		BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, IER5 +5 moreView in SCUBA
Gamma-delta T cellsAnabolic Activation Response
Housekeeping		ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more
Glial cellsDNA Damage Response
Stress		BRD2, FAM53C, GADD45B, IER5, ING1, NFKBIZ, PABPC1, TUBB4B +1 moreView in SCUBA
Goblet cellsRNA Decay Processing
RNA processing & translation		CCNI, ILF2, RBPJ, RSL24D1, SYNCRIP, UBE2I, UBE2R2, XRCC5 +2 moreView in SCUBA
Innate lymphoid cellsIntegrated Stress Response
Stress		AMD1, ATF4, CYCS, DDX5, DNAJB6, EIF1, GPBP1, HERPUD1 +3 moreView in SCUBA
Lymphatic endothelialIntegrated Stress Response
Stress		ATF3, CSRNP1, DDIT3, DNAJA1, EIF4A2, HSP90AB1, PPP1R15A, RSRC2 +2 moreView in SCUBA
MacrophagesRNA Splicing Processing
Housekeeping		ARMCX3, CIRBP, ELK4, GATAD1, H3-3B, HNRNPA2B1, HNRNPA3, HNRNPL +13 moreView in SCUBA
Mucosal-associated invariant T cellDissociation Stress Response
Stress		DUSP1, EIF1, FOS, H3-3B, IER5, SAT1, SRSF7
NeutrophilsRNA Splicing
Housekeeping		ATF4, FUS, HNRNPA2B1, HNRNPA3, IRF2BP2, SFPQ, TRA2B
Smooth muscle cellsChaperonin heat-shock
Stress		CYCS, DUSP1, HSPD1, HSPE1, ODC1, PABPC1, SLC25A25, UBE2D3View in SCUBA

About the gene

SynonymsSFRS3, SRp20
Chromosome6: 36594353-36605600
Predicted locationIntracellular
Essential geneYes
Protein classCancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transport

Function

Splicing factor, which binds the consensus motif 5'- C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA- binding protein that recognizes and binds N6-methyladenosine (m6A)- containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A- containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.