STAT3 transcriptional program
Gene co-expression module in Smooth muscle cells
| Category | Activation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Anchored by STAT3 with cytokine/interferon-associated partners (HLA-E, DDX3X) and a set of broadly expressed transcription factors typical of activated mesenchymal/SMC states (ZBTB20, TCF4, ID4) plus NOLC1 (ribosome biogenesis, a STAT3/growth-responsive target). This reads as a low-grade STAT3-driven transcriptional activation state rather than a full inflammatory cascade (no cytokines/chemokines), and it sits next to other broad regulatory modules (M93, M14) in the neighborhood.
Genes
DDX3X, FAM210B, HLA-E, HNRNPH1, ID4, ITPR1, NOLC1, RAB21, STAT3, TCF4, ZBTB20
Most correlated modules
- BAG3-HSPB8 proteostasis · correlation 0.80
- Translation initiation/RNA-binding · correlation 0.74
- KLF6/ZNF24 regulators · correlation 0.71
- Chaperonin heat-shock · correlation 0.67
- Actin Cytoskeletal Scaffold · correlation 0.66
- NF-kB Stress Response · correlation 0.63
- BMP/TGF-beta response · correlation 0.61
- NR4A-ADAMTS Activation · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.