Immediate Early Response
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 16 genes have a known function matching the annotation |
Why this annotation
Textbook immediate-early gene program: FOS, JUN, JUNB, EGR1, IER2, ATF3, KLF2, KLF4, ZFP36, BTG1/2, GADD45B, SOCS3, CDKN1A, RHOB, HES1. High mean expression, core coherence, uniform across all smooth muscle subsets — the classic signature of tissue dissociation/handling-induced transcription rather than a cell-state-restricted program. It is the anchor of this neighborhood, and its presence supports interpreting neighbors M1, M91 and M28 as successive waves of the same stress-activated cascade.
Genes
ATF3, BTG1, BTG2, CDKN1A, EGR1, FOS, GADD45B, HES1, IER2, JUN, JUNB, KLF2, KLF4, RHOB, SOCS3, ZFP36
Most correlated modules
- Secondary Response Genes · correlation 0.72
- NF-kB Stress Response · correlation 0.71
- Immediate Early Response · correlation 0.70
- NR4A-ADAMTS Activation · correlation 0.70
- Contractile SMC Identity · correlation 0.69
- Chaperonin heat-shock · correlation 0.68
- Vascular SMC Identity · correlation 0.68
- Wnt-Notch Modulation · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.