hnRNP & Proteasome
Gene co-expression module in Smooth muscle cells
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Core is the hnRNP family (HNRNPA3, HNRNPA2B1, HNRNPF, HNRNPU) plus proteostasis machinery (PSMG2, PSMD8, CCT2) and vesicle/GTPase housekeeping (ARF1, GDI2), with WSB1 and ZFP36L1 as peripheral regulators. Shares hnRNP hubs with neighbor M80, defining a nuclear RNA-processing/protein-turnover axis rather than a contractile or inflammatory state.
Genes
ARF1, CCT2, GDI2, HNRNPA2B1, HNRNPA3, HNRNPF, HNRNPU, PSMD8, PSMG2, WSB1, ZFP36L1
Most correlated modules
- mRNA Splicing Factors · correlation 0.78
- Proteasome And Translation · correlation 0.78
- Atrophy Proteolysis Program · correlation 0.75
- Chaperonin heat-shock · correlation 0.74
- Basal metabolic housekeeping · correlation 0.73
- Proliferative Biosynthesis · correlation 0.72
- ER Secretory Trafficking · correlation 0.69
- Sparse Mitoribosomal Housekeeping · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.